Mingdong Huang Selected Research

Urokinase-Type Plasminogen Activator (Urokinase)

10/2022	Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA).
1/2022	Structure-based molecular insights into matrix metalloproteinase inhibitors in cancer treatments.
9/2020	Improved therapeutic efficacy of quercetin-loaded polymeric nanoparticles on triple-negative breast cancer by inhibiting uPA.
1/2020	Plasminogen activator inhibitor (PAI) trap3, an exocellular peptide inhibitor of PAI-1, attenuates the rearrangement of F-actin and migration of cancer cells.
1/2020	Tumor Targeting Chemo- and Photodynamic Therapy Packaged in Albumin for Enhanced Anti-Tumor Efficacy.
12/2019	6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease.
1/2019	Nanoparticle Binding to Urokinase Receptor on Cancer Cell Surface Triggers Nanoparticle Disintegration and Cargo Release.
1/2019	Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
8/2018	Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases.
1/2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.

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Mingdong Huang Research Topics

Disease

53	Neoplasms (Cancer) 10/2022 - 02/2006
15	Thrombosis (Thrombus) 12/2022 - 06/2005
11	Neoplasm Metastasis (Metastasis) 09/2020 - 02/2006
8	Infections 10/2021 - 04/2008
6	Breast Neoplasms (Breast Cancer) 09/2020 - 01/2012
5	Inflammation (Inflammations) 01/2021 - 02/2006
4	Autolysis 01/2021 - 08/2011
3	Hemorrhage 10/2020 - 06/2005
3	Vascular System Injuries 01/2017 - 07/2012
2	Virus Diseases (Viral Diseases) 10/2021 - 02/2017
2	COVID-19 01/2021 - 01/2021
2	Ischemic Stroke 10/2020 - 03/2016
2	Sepsis (Septicemia) 10/2020 - 03/2015
2	Pathologic Processes 01/2020 - 02/2006
2	Hemophilia A (Haemophilia) 07/2019 - 04/2008
2	Phototoxic Dermatitis (Phototoxicity) 10/2018 - 01/2012
2	Carcinoma (Carcinomatosis) 10/2018 - 01/2012
2	Myocardial Infarction 03/2016 - 03/2015
2	Body Weight (Weight, Body) 09/2015 - 04/2015
1	Kidney Diseases (Kidney Disease) 01/2022
1	Chronic Pancreatitis 01/2021
1	Squamous Cell Carcinoma of Head and Neck 01/2021
1	Disseminated Intravascular Coagulation 10/2020
1	Triple Negative Breast Neoplasms 09/2020
1	Hyperglycemia 04/2020
1	Obesity 04/2020
1	Type 2 Diabetes Mellitus (MODY) 04/2020

Drug/Important Bio-Agent (IBA)

24	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 10/2022 - 02/2006
13	Photosensitizing Agents (Photosensitizers)IBA 10/2021 - 06/2010
13	Urokinase Plasminogen Activator ReceptorsIBA 01/2021 - 01/2007
12	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/2020 - 06/2010
7	Peptide Hydrolases (Proteases)FDA Link 01/2022 - 01/2013
7	Serine Proteases (Serine Protease)IBA 10/2021 - 06/2011
7	Pharmaceutical PreparationsIBA 10/2020 - 04/2008
6	Protein Disulfide-IsomerasesIBA 12/2022 - 07/2012
6	Plasminogen Activators (Plasminogen Activator)IBA 10/2022 - 02/2006
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2014
5	Plasminogen Activator Inhibitor 1IBA 04/2020 - 10/2016
5	AlbuminsIBA 01/2020 - 01/2015
5	Zn(II)-phthalocyanine (zinc phthalocyanine)IBA 10/2018 - 01/2012
5	FibrinIBA 10/2016 - 07/2012
4	Fibrinolysin FDA Link 01/2022 - 04/2010
4	matriptaseIBA 10/2021 - 06/2011
4	Peptides (Polypeptides)IBA 01/2020 - 01/2019
4	Human Serum Albumin FDA LinkGeneric 01/2020 - 09/2015
3	Rutin (Rutoside)IBA 12/2022 - 09/2015
3	Drug CarriersIBA 10/2021 - 01/2014
3	Protease Inhibitors (Protease Inhibitor)IBA 01/2021 - 01/2020
3	AnticoagulantsIBA 01/2021 - 06/2005
3	Fibrinolytic Agents (Antithrombotic Agents)IBA 10/2020 - 03/2016
3	Tissue Plasminogen Activator (Alteplase)FDA Link 10/2020 - 03/2016
3	EnzymesIBA 01/2020 - 11/2011
3	trypsin-like serine proteaseIBA 12/2019 - 01/2017
3	Cell Surface ReceptorsIBA 01/2019 - 01/2015
3	Monoclonal AntibodiesIBA 01/2019 - 08/2011
2	IsomerasesIBA 01/2022 - 05/2018
2	Matrix Metalloproteinases (MMPs)IBA 01/2022 - 01/2019
2	Sulfhydryl Compounds (Thiols)IBA 01/2022 - 05/2018
2	Antiviral Agents (Antivirals)IBA 10/2021 - 01/2021
2	Biological ProductsIBA 01/2021 - 03/2011
2	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 01/2021 - 10/2011
2	Amiloride (Midamor)FDA LinkGeneric 12/2019 - 01/2018
2	DiureticsIBA 12/2019 - 01/2018
2	Factor VIII (Coagulation Factor VIII)IBA 07/2019 - 04/2008
2	polydopamineIBA 01/2019 - 05/2018
2	phthalocyanineIBA 10/2018 - 06/2010
2	Therapeutic UsesIBA 08/2018 - 01/2018
2	Biomarkers (Surrogate Marker)IBA 08/2017 - 10/2014
2	Doxorubicin (Adriamycin)FDA LinkGeneric 03/2016 - 01/2015
2	PlasminogenIBA 03/2016 - 10/2007
2	LigandsIBA 03/2015 - 01/2014
2	IntegrinsIBA 01/2014 - 07/2012
2	EpitopesIBA 01/2014 - 08/2011
2	Glycoside Hydrolases (Endoglycosidases)IBA 10/2008 - 04/2007
1	LipidsIBA 12/2022
1	ferric chlorideIBA 12/2022
1	Matrix Metalloproteinase InhibitorsIBA 01/2022
1	ThioredoxinsIBA 01/2022
1	galanginIBA 01/2022
1	endoplasmic reticulum glycoprotein p72IBA 01/2022
1	Protein Isoforms (Isoforms)IBA 01/2022
1	HGF activatorIBA 10/2021
1	phytochlorinIBA 10/2021
1	pentalysineIBA 10/2021
1	ZincIBA 10/2021
1	Platelet Endothelial Cell Adhesion Molecule-1IBA 01/2021
1	camostatIBA 01/2021
1	LipopolysaccharidesIBA 10/2020
1	embelinIBA 10/2020
1	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 10/2020
1	Dacarbazine (DIC)FDA LinkGeneric 10/2020
1	QuercetinIBA 09/2020
1	Blood Glucose (Blood Sugar)IBA 04/2020
1	Lipid Bilayers (Lipid Bilayer)IBA 01/2020
1	Actins (F Actin)IBA 01/2020

Therapy/Procedure

13	Therapeutics 10/2021 - 10/2007
12	Photochemotherapy (Photodynamic Therapy) 01/2020 - 06/2010
5	Drug Therapy (Chemotherapy) 01/2020 - 10/2014
4	Lasers (Laser) 01/2017 - 07/2012
3	Precision Medicine 10/2018 - 06/2015